Innenrücktitelbild: One Polyketide Synthase, Two Distinct Products: Trans ‐Acting Enzyme‐Controlled Product Divergence in Calbistrin Biosynthesis (Angew. Chem. 16/2021)
نویسندگان
چکیده
Die Biosynthese von Calbistrin involviert eine ungewöhnliche dual-funktionelle Polyketid-Synthase, CalA, die beide Teile der Calbistrine synthetisiert. Produktdivergenz wird interessanterweise zwei trans-wirkenden Enzymen kontrolliert, einer Enoylreduktase CalK und C-Methyltransferase CalH, um Decalin- bzw. Polyenanteile zu erhalten. Veresterung beiden Polyketidteile durch Acyltransferase CalD katalysiert, wie Yudai Matsuda, Ikuro Abe et al. in ihrem Forschungsartikel auf S. 8933 berichten.
منابع مشابه
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ژورنال
عنوان ژورنال: Angewandte Chemie
سال: 2021
ISSN: ['1521-3773', '1433-7851', '0570-0833']
DOI: https://doi.org/10.1002/ange.202102305